Fructose Metabolism Chart

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Fructose Metabolic Pathway

Fructose Metabolism Chart

Last Update: November 3, 2024

Picture Fructose Metabolic Routes 

Fructose Metabolism on the Central Metabolism Hub

Note: The following text (in quotations below) was generated with Google Gemini:

“Fructose_a simple sugar, enters the glycolysis pathway through a unique route that differs from glucose.

  • It is first phosphorylated by fructokinase to fructose-1-phosphate (F1P).
  • Unlike glucose-6-phosphate (G6P), fructose-1-phosphate bypasses the regulatory steps of glycolysis.
  • It is then cleaved by aldolase B into dihydroxyacetone phosphate (DHAP) and glyceraldehyde (GA).
  • DHAP can directly enter glycolysis, while
  • glyceraldehyde is phosphorylated to glyceraldehyde-3-phosphate (GA3P), another glycolytic intermediate.”  

“However, the rapid metabolism of fructose_can lead to the production of uric acid.

  • When_fructose is phosphorylated by fructokinase, ATP is used, resulting in the formation of ADP.
  • ADP is further metabolized to AMP, which can be deaminated to uric acid.
    • …uric acid can contribute to hyperuricemia, a condition associated with gout and other health problems.”  

“Additionally, the rapid entry of fructose_metabolites into glycolysis can overwhelm the liver’s capacity to process them, leading to increased fatty acid synthesis and triglyceride accumulation. 

This can contribute to non-alcoholic fatty liver disease and other metabolic disorders.”

Note: The following text (in quotations above) was generated with Google Gemini.

Peter Attia Podcasts on Fructose

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